Ebiosciences 17-5886-82 Anti-Mouse Ly-49H Apc, 100 Ug

Ebiosciences 17-5886-82 Anti-Mouse Ly-49H Apc, 100 Ug

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  • The monoclonal antibody 3D10 recognizes Ly-49H, a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells
  • Ly-49H, like Ly-49D, lacks the characteristic ITIM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors
  • Ly-49H is expressed in a subset of NK cells but not NKT (NK1.1CD3plus) cells
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The monoclonal antibody 3D10 recognizes Ly-49H, a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells.Ly-49H, like Ly-49D, lacks the characteristic ITIM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors.Ly-49H is expressed in a subset of NK cells but not NKT (NK1.1CD3plus) cells. Natural killer cells can express several Ly-49 proteins. It has been shown that there is preferential staining of Ly-49H with Ly-49D (cat 12-5783).Expression has been confirmed on C57BL/6 and NWNA but not Balb/c or DBA/2 mice. Other mice strains have not been tested. No crossreactivity to Ly-49A, C, D or G2 has been observed. Addition of monoclonal antibody 3D10 to cell cultures induces lysis of target cells.

  • The monoclonal antibody 3D10 recognizes Ly-49H, a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells
  • Ly-49H, like Ly-49D, lacks the characteristic ITIM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors
  • Ly-49H is expressed in a subset of NK cells but not NKT (NK1.1CD3plus) cells
Binding

Misc.

Brand

eBiosciences

Label

eBioScience

Manufacturer

eBioScience

Model

17-5886-82

MPN

17-5886-82

PartNumber

17-5886-82

ProductGroup

BISS

ProductTypeName

LAB_SUPPLY

Publisher

eBioScience

Studio

eBioScience

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