Adaptive Design Theory And Implementation Using Sas And R (Chapman & Hall/Crc Biostatistics Series)

Adaptive Design Theory And Implementation Using Sas And R (Chapman & Hall/Crc Biostatistics Series)

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Adaptive design has become an important tool in modern pharmaceutical research and development. Compared to a classic trial design with static features, an adaptive design allows for the modification of the characteristics of ongoing trials based on cumulative information. Adaptive designs increase the probability of success, reduce costs and the time to market, and promote accurate drug delivery to patients.
Reflecting the state of the art in adaptive design approaches, Adaptive Design Theory and Implementation Using SAS and R provides a concise, unified presentation of adaptive design theories, uses SAS and R for the design and simulation of adaptive trials, and illustrates how to master different adaptive designs through real-world examples. The book focuses on simple two-stage adaptive designs with sample size re-estimation before moving on to explore more challenging designs and issues that include drop-loser, adaptive dose-funding, biomarker-adaptive, multiple-endpoint adaptive, response-adaptive randomization, and Bayesian adaptive designs. In many of the chapters, the author compares methods and provides practical examples of the designs, including those used in oncology, cardiovascular, and inflammation trials.
Equipped with the knowledge of adaptive design presented in this book, you will be able to improve the efficiency of your trial design, thereby reducing the time and cost of drug development.

  • Used Book in Good Condition
Author

Mark Chang

Binding

Hardcover

Brand

Brand: Chapman and Hall/CRC

EAN

9781584889625

ISBN

1584889624

Label

Chapman and Hall/CRC

Manufacturer

Chapman and Hall/CRC

NumberOfPages

440

ProductGroup

Book

ProductTypeName

ABIS_BOOK

PublicationDate

2007-06-27

Publisher

Chapman and Hall/CRC

Studio

Chapman and Hall/CRC

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